The Celtics are aiming to bounce back after they were trounced by the revamped Cleveland Cavaliers on Sunday 121-99.
It means Boston have now lost three of their last four leading into their final game before the All-Star break.
They come up against a Clippers side who now longer have Blake Griffin on their roster after he was sensationally traded away last month.
However, they have won four of their last five matches with Lou Williams continuing to impress.
He was rewarded with a new three-year extension last week for what has been a career-high season for him so far.
Boston won the reverse fixtures earlier this season 113-102 and are favourites to return to winning ways.
How to watch Boston Celtics vs LA Clippers on TV
Tonight’s action is scheduled to start at 1:00am GMT and is available to watch on BT Sport 1.
BT Sport is the exclusive home of the NBA in the UK for the 2017/18 season.
They will broadcast up to seven lives games per week throughout the regular season and the first and second rounds of the playoffs, as well as every game of the conference finals and NBA Finals.
How to watch Boston Celtics vs LA Clippers on online
With the game being shown on TV, it will also be available on the BT Sport app.
Alternatively you can sign up for the NBA League Pass with the option of a day pass.
The NBA League Pass lets you watch every NBA game depending on the package you select.
American viewers can catch the action online by also going for the NBA League Pass.